What that, determinants factors of bank's Profitability are divided into two categories: controllable management internal factors and external factors out of the bank management. for the sake of compound these factors and consensus with the literature on profitability that are suggested form appropriate functional for analysis on bank's profitability (well– known linear form). So, regression linear model estimate and analysis for determinants and effective factors of profitability of bank for extend (1362- 80). The finding of this investigation is indicated that management of efficient expensive is one of significantly contributors for high bank's profitability. in addition to, sound asset and liability management have also significant afected for profitability. among the external factors, economic growth also have positive effect on bank's profitability. on the other ways, in flation have had reverse effect on profitability.